Homo sapiens Gene: ADH6
Summary
InnateDB Gene IDBG-31160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH6
Gene Name alcohol dehydrogenase 6 (class V)
Synonyms ADH-5;
Species Homo sapiens
Ensembl Gene ENSG00000172955
Encoded Proteins
alcohol dehydrogenase 6 (class V)
alcohol dehydrogenase 6 (class V)
alcohol dehydrogenase 6 (class V)
alcohol dehydrogenase 6 (class V)
alcohol dehydrogenase 6 (class V)
alcohol dehydrogenase 6 (class V)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5\' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99202638-99219537
Strand Reverse strand
Band q23
Transcripts
ENST00000237653 ENSP00000237653
ENST00000394899 ENSP00000378359
ENST00000394897 ENSP00000378358
ENST00000507484 ENSP00000425275
ENST00000512708 ENSP00000422124
ENST00000508558 ENSP00000426187
ENST00000504257
ENST00000513262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0035276 ethanol binding
Biological Process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism pathway
Biological oxidations pathway
Ethanol oxidation pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.586161
RefSeq NM_000672 NM_001102470 XM_005262731
HUGO
OMIM
CCDS CCDS3647 CCDS43255
HPRD 00067
IMGT
EMBL
GenPept
RNA Seq Atlas