Version 5.4
Homo sapiens Gene: NR2F2
Summary
InnateDB Gene IDBG-31309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR2F2
Gene Name nuclear receptor subfamily 2, group F, member 2
Synonyms ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
Species Homo sapiens
Ensembl Gene ENSG00000185551
Encoded Proteins
IDBP-242156
nuclear receptor subfamily 2, group F, member 2
IDBP-242158
nuclear receptor subfamily 2, group F, member 2
IDBP-380881
nuclear receptor subfamily 2, group F, member 2
IDBP-380885
nuclear receptor subfamily 2, group F, member 2
IDBP-746719
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:96325938-96340263
Strand Forward strand
Band q26.2
Transcripts
ENST00000394171 ENSP00000377726
ENST00000394166 ENSP00000377721
ENST00000421109 ENSP00000401674
ENST00000453270 ENSP00000389853
ENST00000559679 ENSP00000457112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003714 transcription corepressor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001893 maternal placenta development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007519 skeletal muscle tissue development
GO:0009566 fertilization
GO:0009952 anterior/posterior pattern specification
GO:0009956 radial pattern formation
GO:0010596 negative regulation of endothelial cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0030900 forebrain development
GO:0032355 response to estradiol
GO:0043401 steroid hormone mediated signaling pathway
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048514 blood vessel morphogenesis
GO:0060173 limb development
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030551
View Gene Order
ENSBTAG00000018007
Not yet available
Pathways
NETPATH
REACTOME
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
KEGG
INOH
PID NCI
hnf3apathway
FOXA1 transcription factor network
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P24468
TrEMBL H3BTC2
UniProt Splice Variant
Entrez Gene 7026
UniGene Hs.347991 Hs.603510
RefSeq NM_001145157 NM_001145155 NM_001145156 NM_021005
HUGO HGNC:7976
OMIM 107773
CCDS CCDS45359 CCDS10375 CCDS45358
HPRD 00139
IMGT
EMBL AB307711 AC016251 AK298824 AK301595 AK316086 BC014664 BC042897 BC106083 CH471101 FM208183 HQ692849 HQ692850 M62760 M64497 U60477
GenPept AAA21479 AAA86429 AAB09475 AAH14664 AAH42897 AAI06084 ADZ17360 ADZ17361 BAG60954 BAG63083 BAH02302 BAH14457 CAR63888 EAX02195 EAX02196 EAX02197
RNA Seq Atlas 7026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca