InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR2F2

Summary

InnateDB Protein

IDBP-380885.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR2F2

Protein Name

nuclear receptor subfamily 2, group F, member 2

Synonyms

ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000389853

InnateDB Gene

IDBG-31309 (NR2F2)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. {ECO:0000269PubMed:18798693, ECO:0000269PubMed:1899293, ECO:0000269PubMed:9343308}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003714	transcription corepressor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0010596	negative regulation of endothelial cell migration
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104

PRINTS

PR00545
PR00398
PR00546
PR01282

PIRSF

SMART

SM00430

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt