InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPCAT2

Summary

InnateDB Gene

IDBG-31324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPCAT2

Gene Name

lysophosphatidylcholine acyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000087253

Encoded Proteins

IDBP-31326

lysophosphatidylcholine acyltransferase 2

IDBP-749847

IDBP-807768

lysophosphatidylcholine acyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20663880

LPCAT2 is highly expressed in inflammatory cells and is activated by lipopolysaccharide (LPS) treatment through Toll-like receptor 4 (TLR4) and LPCAT2 phosphorylation through LPS-TLR4 signalling may directly depend on MAPK-activated protein kinase 2 (MAPKAPK2).

Entrez Gene

Summary

This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:55508998-55586670

Strand

Forward strand

Band

q12.2

Transcripts

ENST00000262134	ENSP00000262134
ENST00000564084	ENSP00000457496
ENST00000562299
ENST00000566911
ENST00000566915
ENST00000565056
ENST00000566375
ENST00000563095
ENST00000615823	ENSP00000483225

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006663	platelet activating factor biosynthetic process
GO:0008152	metabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046474	glycerophospholipid biosynthetic process
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005795	Golgi stack
GO:0005811	lipid particle
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033192

View Gene Order

ENSBTAG00000019272

Not yet available

Pathways

NETPATH

REACTOME

REACT_120829

Acyl chain remodelling of PC pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa00565

Ether lipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.460857

RefSeq

NM_017839 XM_006721211

HUGO

OMIM

CCDS

CCDS10753

HPRD

07913

IMGT

EMBL

GenPept

RNA Seq Atlas