Version 5.4
Homo sapiens Gene: GEN1
Summary
InnateDB Gene IDBG-31446.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GEN1
Gene Name Gen endonuclease homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178295
Encoded Proteins
IDBP-31448
Gen homolog 1, endonuclease (Drosophila)
IDBP-31450
Gen homolog 1, endonuclease (Drosophila)
IDBP-585580
Gen homolog 1, endonuclease (Drosophila)
IDBP-589301
Gen homolog 1, endonuclease (Drosophila)
IDBP-810693
GEN1 Holliday junction 5' flap endonuclease
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:17753858-17788941
Strand Forward strand
Band p24.2
Transcripts
ENST00000317402 ENSP00000318977
ENST00000381254 ENSP00000370653
ENST00000524465 ENSP00000435143
ENST00000532257 ENSP00000433180
ENST00000534669
ENST00000528873
ENST00000534451 ENSP00000481385
ENST00000614478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0008821 crossover junction endodeoxyribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0010824 regulation of centrosome duplication
GO:0071139 resolution of recombination intermediates
GO:0071140 resolution of mitotic recombination intermediates
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051235
View Gene Order
ENSBTAG00000020059
Not yet available
Cross-References
SwissProt
TrEMBL E9PLG0 E9PM30
UniProt Splice Variant
Entrez Gene 348654
UniGene Hs.467793
RefSeq NM_001130009 NM_182625 XM_005262613 XM_006712005 XM_006712006
HUGO HGNC:26881
OMIM 612449
CCDS CCDS1691
HPRD 08813
IMGT
EMBL AC093731 AC097377
GenPept
RNA Seq Atlas 348654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca