Homo sapiens Gene: NT5C1B
Summary
InnateDB Gene IDBG-31655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5C1B
Gene Name 5'-nucleotidase, cytosolic IB
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185013
Encoded Proteins
5'-nucleotidase, cytosolic IB
5'-nucleotidase, cytosolic IB
5'-nucleotidase, cytosolic IB
5'-nucleotidase, cytosolic IB
5'-nucleotidase, cytosolic IB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010] Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:18562872-18589572
Strand Reverse strand
Band p24.2
Transcripts
ENST00000359846 ENSP00000352904
ENST00000304081 ENSP00000305979
ENST00000406971 ENSP00000383905
ENST00000418427 ENSP00000390811
ENST00000416783 ENSP00000401656
ENST00000490687
ENST00000460052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Purine catabolism pathway
Metabolism of nucleotides pathway
Purine metabolism pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
Nicotinate and nicotinamide metabolism pathway
Purine metabolism pathway
INOH
Nicotinate Nicotinamide metabolism pathway
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL C4AM88
UniProt Splice Variant
Entrez Gene 93034
UniGene
RefSeq NM_001002006 NM_001199086 NM_001199087 NM_001199088 NM_033253
HUGO HGNC:17818
OMIM 610526
CCDS CCDS33149 CCDS33150
HPRD 11405
IMGT
EMBL AC079148
GenPept
RNA Seq Atlas 93034