Version 5.4
Homo sapiens Protein: NT5C1B
Summary
InnateDB Protein IDBP-31665.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5C1B
Protein Name 5'-nucleotidase, cytosolic IB
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305979
InnateDB Gene IDBG-31655 (NT5C1B)
Protein Structure
UniProt Annotation
Function Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung. {ECO:0000269PubMed:11690631}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR010394 5-nucleotidase
PFAM PF06189
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P26
PhosphoSite PhosphoSite-Q96P26
TrEMBL
UniProt Splice Variant
Entrez Gene 93034
UniGene
RefSeq NP_150278
HUGO HGNC:17818
OMIM 610526
CCDS CCDS33149
HPRD 11405
IMGT
EMBL AC079148 AF352326 AF356185 AF417165 AJ295254 AK057444 AK093234 AK093464 BC136387 BC171761 CH471053
GenPept AAI36388 AAI71761 AAK39108 AAK83285 AAL11910 AAX93260 BAB71489 BAC04103 BAC04174 CAC44363 EAX00853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca