Homo sapiens Gene: KCNJ6
Summary
InnateDB Gene IDBG-3209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ6
Gene Name potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms BIR1; GIRK-2; GIRK2; hiGIRK2; KATP-2; KATP2; KCNJ7; KIR3.2;
Species Homo sapiens
Ensembl Gene ENSG00000157542
Encoded Proteins
potassium inwardly-rectifying channel, subfamily J, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:37607376-37916446
Strand Reverse strand
Band q22.13
Transcripts
ENST00000609713 ENSP00000477437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005515 protein binding
GO:0015467 G-protein activated inward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Neuronal System pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Activation of GABAB receptors pathway
Inwardly rectifying K+ channels pathway
Potassium Channels pathway
GABA B receptor activation pathway
Transmission across Chemical Synapses pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Activation of G protein gated Potassium channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P48051
TrEMBL
UniProt Splice Variant
Entrez Gene 3763
UniGene
RefSeq NM_002240
HUGO HGNC:6267
OMIM 600877
CCDS CCDS42927
HPRD
IMGT
EMBL BC101547 D87327 G02354 L78480 S78684 S78685 U24660 U52153
GenPept AAB02277 AAB07044 AAB34738 AAC50258 AAI01548 BAA13331
RNA Seq Atlas 3763