InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNJ6

Summary

InnateDB Gene

IDBG-3209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ6

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 6

Synonyms

BIR1; GIRK-2; GIRK2; hiGIRK2; KATP-2; KATP2; KCNJ7; KIR3.2

Species

Homo sapiens

Ensembl Gene

ENSG00000157542

Encoded Proteins

IDBP-811023

potassium inwardly-rectifying channel, subfamily J, member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:37607376-37916446

Strand

Reverse strand

Band

q22.13

Transcripts

ENST00000609713

ENSP00000477437

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0015467	G-protein activated inward rectifier potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0071805	potassium ion transmembrane transport