Homo sapiens Gene: RB1
InnateDB Gene IDBG-32092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RB1
Gene Name retinoblastoma 1
Synonyms OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
Species Homo sapiens
Ensembl Gene ENSG00000139687
Encoded Proteins
retinoblastoma 1
retinoblastoma 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
RB1 positively regulates TLR3 expression by modulating the transcription factor E2F1. (Demonstrated in mice)
InnateDB Annotation from Orthologs
[Mus musculus] Rb1 positively regulates Tlr3 expression by modulating the transcription factor E2f1.
Entrez Gene
Summary The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48303751-48481986
Strand Forward strand
Band q14.2
ENST00000267163 ENSP00000267163
ENST00000467505 ENSP00000434702
Number of Interactions This gene and/or its encoded proteins are associated with 479 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 479 [view]
Protein-Protein 427 [view]
Protein-DNA 47 [view]
Protein-RNA 0
DNA-DNA 5 [view]
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0050681 androgen receptor binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007050 cell cycle arrest
GO:0007070 negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007093 mitotic cell cycle checkpoint
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0008150 biological_process
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral process
GO:0030182 neuron differentiation
GO:0030521 androgen receptor signaling pathway
GO:0031134 sister chromatid biorientation
GO:0031175 neuron projection development
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034349 glial cell apoptotic process
GO:0035914 skeletal muscle cell differentiation
GO:0042551 neuron maturation
GO:0043353 enucleate erythrocyte differentiation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043550 regulation of lipid kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045445 myoblast differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0071459 protein localization to chromosome, centromeric region
GO:0071922 regulation of cohesin localization to chromatin
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090230 regulation of centromere complex assembly
GO:0097284 hepatocyte apoptotic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000785 chromatin
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005819 spindle
GO:0016514 SWI/SNF complex
GO:0016605 PML body
GO:0035189 Rb-E2F complex
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
AndrogenReceptor pathway
ID pathway
TGF_beta_Receptor pathway
TNFalpha pathway
BCR pathway
IL1 pathway
IL3 pathway
IL6 pathway
TSH pathway
Prolactin pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Cyclin D associated events in G1 pathway
DNA Replication pathway
G1 Phase pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
Condensation of Prophase Chromosomes pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Prophase pathway
Cell Cycle, Mitotic pathway
Regulation of DNA replication pathway
Non-small cell lung cancer pathway
Cell cycle pathway
Melanoma pathway
Bladder cancer pathway
Glioma pathway
Small cell lung cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Pathways in cancer pathway
Regulation of retinoblastoma protein
Direct p53 effectors
ATF-2 transcription factor network
Notch-mediated HES/HEY network
p73 transcription factor network
E2F transcription factor network
FOXM1 transcription factor network
UniProt Splice Variant
Entrez Gene
UniGene Hs.408528 Hs.605217
RefSeq NM_000321
HPRD 01574
RNA Seq Atlas