Homo sapiens Gene: EPHB4
Summary
InnateDB Gene IDBG-32108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHB4
Gene Name EPH receptor B4
Synonyms HTK; MYK1; TYRO11;
Species Homo sapiens
Ensembl Gene ENSG00000196411
Encoded Proteins
EPH receptor B4
EPH receptor B4
EPH receptor B4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100802565-100827521
Strand Reverse strand
Band q22.1
Transcripts
ENST00000358173 ENSP00000350896
ENST00000360620 ENSP00000353833
ENST00000487222
ENST00000492403
ENST00000478459
ENST00000467515
ENST00000477446
ENST00000489808
ENST00000492878
ENST00000616502 ENSP00000482702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003007 heart morphogenesis
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Ephrin signaling pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
EPHB forward signaling
Ephrin B reverse signaling
EphrinB-EPHB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437008 Hs.613896
RefSeq NM_004444
HUGO
OMIM
CCDS CCDS5706
HPRD 02481
IMGT
EMBL
GenPept
RNA Seq Atlas