Homo sapiens Gene: ALDH1A3
Summary
InnateDB Gene IDBG-32178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1A3
Gene Name aldehyde dehydrogenase 1 family, member A3
Synonyms ALDH1A6; ALDH6; MCOP8; RALDH3;
Species Homo sapiens
Ensembl Gene ENSG00000184254
Encoded Proteins
aldehyde dehydrogenase 1 family, member A3
aldehyde dehydrogenase 1 family, member A3
aldehyde dehydrogenase 1 family, member A3
aldehyde dehydrogenase 1 family, member A3
aldehyde dehydrogenase 1 family, member A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008]
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:100877714-100916626
Strand Forward strand
Band q26.3
Transcripts
ENST00000329841 ENSP00000332256
ENST00000346623 ENSP00000343294
ENST00000558568
ENST00000561338 ENSP00000452789
ENST00000558033 ENSP00000454107
ENST00000557963 ENSP00000453328
ENST00000560555
ENST00000558869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0070324 thyroid hormone binding
GO:0070403 NAD+ binding
Biological Process
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002138 retinoic acid biosynthetic process
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0021768 nucleus accumbens development
GO:0031076 embryonic camera-type eye development
GO:0042472 inner ear morphogenesis
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0043065 positive regulation of apoptotic process
GO:0048048 embryonic eye morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0055114 oxidation-reduction process
GO:0060013 righting reflex
GO:0060166 olfactory pit development
GO:0060324 face development
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycolysis / Gluconeogenesis pathway
Histidine metabolism pathway
Tyrosine metabolism pathway
Phenylalanine metabolism pathway
beta-Alanine metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Histidine degradation pathway
Phenylalanine degradation pathway
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YKF9
UniProt Splice Variant
Entrez Gene 220
UniGene Hs.459538 Hs.685048
RefSeq NM_000693 NM_001293815
HUGO HGNC:409
OMIM 600463
CCDS CCDS10389
HPRD 02713
IMGT
EMBL AC015712
GenPept
RNA Seq Atlas 220