|Homo sapiens Gene: IL25|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 25|
|Useful resources||Stemformatics EHFPI ImmGen|
IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative multipotent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T(H)2 cytokine responses, presenting an innate immune pathway that promotes T(H)2 cytokine responses at mucosal sites.
|InnateDB Annotation from Orthologs|
[Mus musculus] Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
[Mus musculus] Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
|Genomic Location||Chromosome 14:23372809-23376403|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
|UniProt Splice Variant|
|EMBL||AF305200 AF458059 AF461739 AY359127 BC069565 BC104929 BC104931 CH471078|
|GenPept||AAG40848 AAH69565 AAI04930 AAI04932 AAL57622 AAN39038 AAQ89484 EAW66162|
|RNA Seq Atlas||64806|