Homo sapiens Gene: IL25
Summary
InnateDB Gene IDBG-3218.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL25
Gene Name interleukin 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166090
Encoded Proteins
interleukin 25
interleukin 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative multipotent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T(H)2 cytokine responses, presenting an innate immune pathway that promotes T(H)2 cytokine responses at mucosal sites.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
[Mus musculus] Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.
Entrez Gene
Summary The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23372809-23376403
Strand Forward strand
Band q11.2
Transcripts
ENST00000329715 ENSP00000328111
ENST00000397242 ENSP00000380417
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0030380 interleukin-17E receptor binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006954 inflammatory response
GO:0008150 biological_process
GO:0009620 response to fungus
GO:0009624 response to nematode
GO:0030222 eosinophil differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H293
TrEMBL
UniProt Splice Variant
Entrez Gene 64806
UniGene Hs.302036
RefSeq NM_022789 NM_172314
HUGO HGNC:13765
OMIM 605658
CCDS CCDS45086 CCDS9597
HPRD
IMGT
EMBL AF305200 AF458059 AF461739 AY359127 BC069565 BC104929 BC104931 CH471078
GenPept AAG40848 AAH69565 AAI04930 AAI04932 AAL57622 AAN39038 AAQ89484 EAW66162
RNA Seq Atlas 64806