Version 5.4
Homo sapiens Gene: LRRK1
Summary
InnateDB Gene IDBG-32229.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRK1
Gene Name leucine-rich repeat kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154237
Encoded Proteins
IDBP-32233
leucine-rich repeat kinase 1
IDBP-588181
leucine-rich repeat kinase 1
IDBP-596324
leucine-rich repeat kinase 1
IDBP-596526
leucine-rich repeat kinase 1
IDBP-585374
leucine-rich repeat kinase 1
IDBP-593321
leucine-rich repeat kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:100919215-101078254
Strand Forward strand
Band q26.3
Transcripts
ENST00000388948 ENSP00000373600
ENST00000534045 ENSP00000435148
ENST00000527698
ENST00000532029 ENSP00000433268
ENST00000525284 ENSP00000433069
ENST00000531270 ENSP00000431668
ENST00000525617
ENST00000538064
ENST00000526457 ENSP00000436672
ENST00000525395
ENST00000532145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007264 small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015133
View Gene Order
ENSBTAG00000001567
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 79705
UniGene Hs.407918 Hs.640589
RefSeq NM_024652 XM_005254979
HUGO HGNC:18608
OMIM 610986
CCDS CCDS42086
HPRD 14319
IMGT
EMBL
GenPept
RNA Seq Atlas 79705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca