InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRK1

Summary

InnateDB Protein

IDBP-32233.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRK1

Protein Name

leucine-rich repeat kinase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373600

InnateDB Gene

IDBG-32229 (LRRK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16243488}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	82 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001611 Leucine-rich repeat
IPR001806 Small GTPase superfamily
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003591 Leucine-rich repeat, typical subtype
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011009 Protein kinase-like domain
IPR013684 Mitochondrial Rho-like
IPR017986 WD40-repeat-containing domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM