Version 5.4
Homo sapiens Gene: PUM2
Summary
InnateDB Gene IDBG-32267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUM2
Gene Name pumilio homolog 2 (Drosophila)
Synonyms PUMH2; PUML2
Species Homo sapiens
Ensembl Gene ENSG00000055917
Encoded Proteins
IDBP-32269
pumilio homolog 2 (Drosophila)
IDBP-32271
pumilio homolog 2 (Drosophila)
IDBP-32275
pumilio homolog 2 (Drosophila)
IDBP-294991
pumilio homolog 2 (Drosophila)
IDBP-365478
pumilio homolog 2 (Drosophila)
IDBP-365491
pumilio homolog 2 (Drosophila)
IDBP-365494
pumilio homolog 2 (Drosophila)
IDBP-365495
pumilio homolog 2 (Drosophila)
IDBP-365496
pumilio homolog 2 (Drosophila)
IDBP-365498
pumilio homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:20248691-20352234
Strand Reverse strand
Band p24.1
Transcripts
ENST00000338086 ENSP00000338173
ENST00000361078 ENSP00000354370
ENST00000319801 ENSP00000326746
ENST00000403432 ENSP00000385992
ENST00000440577 ENSP00000409905
ENST00000442400 ENSP00000387399
ENST00000420234
ENST00000429419 ENSP00000396727
ENST00000432105 ENSP00000408384
ENST00000446940 ENSP00000413515
ENST00000424110 ENSP00000395098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
GO:0034063 stress granule assembly
Cellular Component
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020594
View Gene Order
ENSBTAG00000011155
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467824 Hs.597674 Hs.610661 Hs.713755
RefSeq NM_001282752 NM_001282790 NM_001282791 NM_015317 XM_005262607 XM_005262609 XM_005262610 XM_006711972 XM_006711973 XM_006711974 XM_006711975
HUGO
OMIM
CCDS CCDS1698 CCDS74486 CCDS74487
HPRD 09527
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca