Version 5.4
Homo sapiens Gene: PARVA
Summary
InnateDB Gene IDBG-32473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARVA
Gene Name parvin, alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197702
Encoded Proteins
IDBP-32475
parvin, alpha
IDBP-584424
parvin, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:12377185-12530801
Strand Forward strand
Band p15.3
Transcripts
ENST00000334956 ENSP00000334008
ENST00000530755
ENST00000533345
ENST00000528916 ENSP00000435860
ENST00000526746
ENST00000533392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0002040 sprouting angiogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0008360 regulation of cell shape
GO:0031532 actin cytoskeleton reorganization
GO:0034113 heterotypic cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0060271 cilium morphogenesis
GO:0070252 actin-mediated cell contraction
GO:0071670 smooth muscle cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030770
View Gene Order
ENSBTAG00000000700
Not yet available
Pathways
NETPATH
REACTOME
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20617
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
hsa04510
Focal adhesion pathway
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL E9PS97
UniProt Splice Variant
Entrez Gene 55742
UniGene Hs.432914 Hs.623587
RefSeq NM_018222 XM_005253015
HUGO HGNC:14652
OMIM 608120
CCDS CCDS44541
HPRD 16283
IMGT
EMBL AC009806 AC025300
GenPept
RNA Seq Atlas 55742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca