Version 5.4
Homo sapiens Gene: ACHE
Summary
InnateDB Gene IDBG-32513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACHE
Gene Name acetylcholinesterase
Synonyms ACEE; ARACHE; N-ACHE; YT
Species Homo sapiens
Ensembl Gene ENSG00000087085
Encoded Proteins
IDBP-32515
acetylcholinesterase
IDBP-32517
acetylcholinesterase
IDBP-384043
acetylcholinesterase
IDBP-384050
acetylcholinesterase
IDBP-384051
acetylcholinesterase
IDBP-384052
acetylcholinesterase
IDBP-384053
acetylcholinesterase
IDBP-384055
acetylcholinesterase
IDBP-384058
acetylcholinesterase
IDBP-384059
acetylcholinesterase
IDBP-384063
acetylcholinesterase
IDBP-384066
acetylcholinesterase
IDBP-384067
acetylcholinesterase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18385943
ACHE (acetylcholinesterase) expression is induced by hydrogen peroxide (H2O2) via the JNK/AP1/ ATF2 signalling pathway.
Entrez Gene
Summary Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100889994-100896974
Strand Reverse strand
Band q22.1
Transcripts
ENST00000241069 ENSP00000241069
ENST00000302913 ENSP00000303211
ENST00000428317 ENSP00000414858
ENST00000419336 ENSP00000403474
ENST00000412389 ENSP00000394976
ENST00000426415 ENSP00000397143
ENST00000430554 ENSP00000399725
ENST00000454485 ENSP00000390004
ENST00000440755 ENSP00000410380
ENST00000442452 ENSP00000415901
ENST00000411582 ENSP00000404865
ENST00000441605 ENSP00000396360
ENST00000445236 ENSP00000400933
ENST00000619863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0016787 hydrolase activity
GO:0017171 serine hydrolase activity
GO:0042166 acetylcholine binding
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding
GO:0043621 protein self-association
Biological Process
GO:0001507 acetylcholine catabolic process in synaptic cleft
GO:0001919 regulation of receptor recycling
GO:0002076 osteoblast development
GO:0006260 DNA replication
GO:0006581 acetylcholine catabolic process
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0007517 muscle organ development
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0009611 response to wounding
GO:0019695 choline metabolic process
GO:0031623 receptor internalization
GO:0032223 negative regulation of synaptic transmission, cholinergic
GO:0042136 neurotransmitter biosynthetic process
GO:0042982 amyloid precursor protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045212 neurotransmitter receptor biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0048814 regulation of dendrite morphogenesis
GO:0050714 positive regulation of protein secretion
GO:0050770 regulation of axonogenesis
GO:0051262 protein tetramerization
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005576 extracellular region
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031225 anchored component of membrane
GO:0031594 neuromuscular junction
GO:0042734 presynaptic membrane
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023328
View Gene Order
ENSBTAG00000001139
Not yet available
Pathways
NETPATH
REACTOME
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_121238
Synthesis of PC pathway
REACT_13583
Neurotransmitter Clearance In The Synaptic Cleft pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13685
Neuronal System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_17015
Metabolism of proteins pathway
REACT_120870
Phospholipid metabolism pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
atf2_pathway
ATF-2 transcription factor network
Cross-References
SwissProt P22303
TrEMBL C9J2S3 C9JD78 C9JUK5 C9JZL6 F8WAR7 F8WD34 F8WD68 Q6TQD3
UniProt Splice Variant
Entrez Gene 43
UniGene Hs.154495
RefSeq NM_000665 NM_001282449 NM_015831 XM_005250357 XM_005250358 XM_006715994 XM_006715995
HUGO HGNC:108
OMIM 100740
CCDS CCDS5709 CCDS5710 CCDS64736
HPRD
IMGT
EMBL AC011895 AF312032 AF334270 AK223443 AK291321 AY389977 AY750146 BC036813 BC105060 BC105062 BC143469 CH236956 CH471091 M55040 S71129
GenPept AAA68151 AAC60618 AAH36813 AAI05061 AAI05063 AAI43470 AAK21003 AAO32948 AAP22364 AAP22365 AAR26654 AAU43801 BAD97163 BAF84010 EAL23812 EAL23813 EAW76461 EAW76462 EAW76463
RNA Seq Atlas 43

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca