InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACHE

Summary

InnateDB Protein

IDBP-384043.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACHE

Protein Name

acetylcholinesterase

Synonyms

ACEE; ARACHE; N-ACHE; YT;

Species

Homo sapiens

Ensembl Protein

ENSP00000414858

InnateDB Gene

IDBG-32513 (ACHE)

Protein Structure

UniProt Annotation

Function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. {ECO:0000269PubMed:11985878, ECO:0000269PubMed:1517212, ECO:0000269PubMed:1748670, ECO:0000269PubMed:2714437}.

Subcellular Localization

Cell junction, synapse {ECO:0000269PubMed:11985878, ECO:0000269PubMed:1748670}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.Isoform T: Nucleus. Note=Only observed in apoptotic nuclei.Isoform H: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform H is highly expressed in erythrocytes. {ECO:0000269PubMed:2714437}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0016787	hydrolase activity
GO:0017171	serine hydrolase activity
GO:0042166	acetylcholine binding
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding

Biological Process

GO:0001507	acetylcholine catabolic process in synaptic cleft
GO:0002076	osteoblast development
GO:0006260	DNA replication
GO:0006581	acetylcholine catabolic process
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0007155	cell adhesion
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0007399	nervous system development
GO:0007416	synapse assembly
GO:0007517	muscle organ development
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0009611	response to wounding
GO:0019695	choline metabolic process
GO:0032223	negative regulation of synaptic transmission, cholinergic
GO:0042136	neurotransmitter biosynthetic process
GO:0042982	amyloid precursor protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046474	glycerophospholipid biosynthetic process
GO:0048814	regulation of dendrite morphogenesis
GO:0050714	positive regulation of protein secretion
GO:0050770	regulation of axonogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031225	anchored component of membrane
GO:0031594	neuromuscular junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00135
PF07859
PF08674

PRINTS

PR00878

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22303