InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CETP

Summary

InnateDB Gene

IDBG-32674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CETP

Gene Name

cholesteryl ester transfer protein, plasma

Synonyms

BPIFF; HDLCQ10

Species

Homo sapiens

Ensembl Gene

ENSG00000087237

Encoded Proteins

IDBP-32676

cholesteryl ester transfer protein, plasma

IDBP-32678

cholesteryl ester transfer protein, plasma

IDBP-745356

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:56961850-56983845

Strand

Forward strand

Band

q13

Transcripts

ENST00000200676	ENSP00000200676
ENST00000379780	ENSP00000369106
ENST00000569082
ENST00000566128	ENSP00000456276

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005548	phospholipid transporter activity
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0017129	triglyceride binding
GO:0031210	phosphatidylcholine binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0008203	cholesterol metabolic process
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010874	regulation of cholesterol efflux
GO:0015914	phospholipid transport
GO:0030301	cholesterol transport
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0055088	lipid homeostasis
GO:0055091	phospholipid homeostasis
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031982	vesicle
GO:0034364	high-density lipoprotein particle
GO:0070062	extracellular vesicular exosome