Homo sapiens Gene: CETP
Summary
InnateDB Gene IDBG-32674.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CETP
Gene Name cholesteryl ester transfer protein, plasma
Synonyms BPIFF; HDLCQ10;
Species Homo sapiens
Ensembl Gene ENSG00000087237
Encoded Proteins
cholesteryl ester transfer protein, plasma
cholesteryl ester transfer protein, plasma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56961850-56983845
Strand Forward strand
Band q13
Transcripts
ENST00000200676 ENSP00000200676
ENST00000379780 ENSP00000369106
ENST00000569082
ENST00000566128 ENSP00000456276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005548 phospholipid transporter activity
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
GO:0017129 triglyceride binding
GO:0031210 phosphatidylcholine binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006869 lipid transport
GO:0006898 receptor-mediated endocytosis
GO:0008203 cholesterol metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010874 regulation of cholesterol efflux
GO:0015914 phospholipid transport
GO:0030301 cholesterol transport
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0044281 small molecule metabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031982 vesicle
GO:0034364 high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
HDL-mediated lipid transport pathway
Orphan transporters pathway
Lipoprotein metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
LDL-mediated lipid transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P11597
TrEMBL H3BRJ9 Q8IWL9 Q9H4L8
UniProt Splice Variant
Entrez Gene 1071
UniGene Hs.89538
RefSeq NM_000078 NM_001286085 XM_006721124
HUGO HGNC:1869
OMIM 118470
CCDS CCDS10772 CCDS67032
HPRD
IMGT
EMBL AC012181 AC023825 AF027656 AY008270 AY172980 AY422211 BC025739 M30185 M32992 M32993 M32994 M32995 M32996 M32997 M32998 M83573 U71187
GenPept AAA51977 AAA51978 AAB59388 AAB86604 AAD14876 AAG21822 AAH25739 AAO12735 AAR03500
RNA Seq Atlas 1071