InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CETP

Summary

InnateDB Protein

IDBP-32676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CETP

Protein Name

cholesteryl ester transfer protein, plasma

Synonyms

BPIFF; HDLCQ10;

Species

Homo sapiens

Ensembl Protein

ENSP00000200676

InnateDB Gene

IDBG-32674 (CETP)

Protein Structure

UniProt Annotation

Function

Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269PubMed:12091484, ECO:0000269PubMed:2215607, ECO:0000269PubMed:8408659}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005548	phospholipid transporter activity
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0017129	triglyceride binding
GO:0031210	phosphatidylcholine binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0008203	cholesterol metabolic process
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010874	regulation of cholesterol efflux
GO:0015914	phospholipid transport
GO:0030301	cholesterol transport
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0055088	lipid homeostasis
GO:0055091	phospholipid homeostasis
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031982	vesicle
GO:0034364	high-density lipoprotein particle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017130 Cholesteryl ester transfer
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

PIRSF037185

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt