Version 5.4
Homo sapiens Gene: RCBTB2
Summary
InnateDB Gene IDBG-32679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCBTB2
Gene Name regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms CHC1L; RLG
Species Homo sapiens
Ensembl Gene ENSG00000136161
Encoded Proteins
IDBP-32681
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
IDBP-368107
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
IDBP-600925
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
IDBP-583295
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. [provided by RefSeq, Jul 2008]
This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48488959-48533256
Strand Reverse strand
Band q14.2
Transcripts
ENST00000344532 ENSP00000345144
ENST00000430805 ENSP00000389910
ENST00000462703
ENST00000481144
ENST00000544492 ENSP00000443862
ENST00000544904 ENSP00000443904
ENST00000611827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032853 positive regulation of Ran GTPase activity
Cellular Component
GO:0001669 acrosomal vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022106
View Gene Order
ENSBTAG00000006647
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.652712 Hs.721400
RefSeq NM_001268 NM_001286830 NM_001286831 NM_001286832 XM_005266242 XM_005266244 XM_006719759
HUGO
OMIM
CCDS CCDS73570 CCDS73571 CCDS73572 CCDS9411
HPRD 04631
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca