Version 5.4
Homo sapiens Gene: PITPNB
Summary
InnateDB Gene IDBG-3283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PITPNB
Gene Name phosphatidylinositol transfer protein, beta
Synonyms PI-TP-beta; PtdInsTP; VIB1B
Species Homo sapiens
Ensembl Gene ENSG00000180957
Encoded Proteins
IDBP-3285
phosphatidylinositol transfer protein, beta
IDBP-3287
phosphatidylinositol transfer protein, beta
IDBP-369199
phosphatidylinositol transfer protein, beta
IDBP-369204
phosphatidylinositol transfer protein, beta
IDBP-369209
phosphatidylinositol transfer protein, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. [provided by RefSeq, Jul 2008]
This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:27851669-27920134
Strand Reverse strand
Band q12.1
Transcripts
ENST00000335272 ENSP00000334738
ENST00000320996 ENSP00000321266
ENST00000455418 ENSP00000405179
ENST00000415296 ENSP00000406542
ENST00000436663 ENSP00000403675
ENST00000477861
ENST00000493007
ENST00000465179
ENST00000460566
ENST00000471825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006810 transport
GO:0015914 phospholipid transport
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050017
View Gene Order
ENSBTAG00000017799
Not yet available
Pathways
NETPATH
REACTOME
REACT_121079
PI and PC transport between ER and Golgi membranes pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.705323 Hs.7370
RefSeq NM_001284277 NM_001284278 NM_012399
HUGO
OMIM
CCDS CCDS13842 CCDS63433
HPRD 06044
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca