Version 5.4
Homo sapiens Gene: RRAS2
Summary
InnateDB Gene IDBG-33051.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RRAS2
Gene Name related RAS viral (r-ras) oncogene homolog 2
Synonyms TC21
Species Homo sapiens
Ensembl Gene ENSG00000133818
Encoded Proteins
IDBP-33053
related RAS viral (r-ras) oncogene homolog 2
IDBP-367235
related RAS viral (r-ras) oncogene homolog 2
IDBP-597484
related RAS viral (r-ras) oncogene homolog 2
IDBP-589990
related RAS viral (r-ras) oncogene homolog 2
IDBP-596382
related RAS viral (r-ras) oncogene homolog 2
IDBP-602481
related RAS viral (r-ras) oncogene homolog 2
IDBP-590758
related RAS viral (r-ras) oncogene homolog 2
IDBP-595294
related RAS viral (r-ras) oncogene homolog 2
IDBP-586770
related RAS viral (r-ras) oncogene homolog 2
IDBP-585597
related RAS viral (r-ras) oncogene homolog 2
IDBP-588433
related RAS viral (r-ras) oncogene homolog 2
IDBP-596309
related RAS viral (r-ras) oncogene homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:14277926-14364506
Strand Reverse strand
Band p15.2
Transcripts
ENST00000256196 ENSP00000256196
ENST00000414023 ENSP00000403282
ENST00000529237 ENSP00000433230
ENST00000534746 ENSP00000437083
ENST00000526063 ENSP00000434104
ENST00000532814 ENSP00000431954
ENST00000531807 ENSP00000435453
ENST00000532950 ENSP00000436190
ENST00000531421 ENSP00000432559
ENST00000526717 ENSP00000436887
ENST00000537760 ENSP00000437547
ENST00000545643 ENSP00000441722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0009987 cellular process
GO:0015031 protein transport
GO:0030335 positive regulation of cell migration
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055723
View Gene Order
ENSBTAG00000011905
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502004
RefSeq NM_001102669 NM_001177314 NM_001177315 NM_012250
HUGO
OMIM
CCDS CCDS44544 CCDS53603 CCDS7814
HPRD 02518
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca