InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD97

Summary

InnateDB Gene

IDBG-33120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD97

Gene Name

CD97 molecule

Synonyms

TM7LN1

Species

Homo sapiens

Ensembl Gene

ENSG00000123146

Encoded Proteins

IDBP-33122

CD97 molecule

IDBP-33124

CD97 molecule

IDBP-33126

CD97 molecule

IDBP-765466

IDBP-763509

IDBP-759749

IDBP-760536

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21706400

CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.

InnateDB Annotation from Orthologs

Summary

PMID 21706400

[Mus musculus] Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.

Entrez Gene

Summary

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:14380501-14408725

Strand

Forward strand

Band

p13.12

Transcripts

ENST00000242786	ENSP00000242786
ENST00000357355	ENSP00000349918
ENST00000358600	ENSP00000351413
ENST00000586517	ENSP00000467351
ENST00000586849
ENST00000587728
ENST00000590567
ENST00000592341
ENST00000587535
ENST00000593028
ENST00000591080	ENSP00000466040
ENST00000592261	ENSP00000467478
ENST00000587606	ENSP00000465800
ENST00000591737
ENST00000591565
ENST00000587319

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002885

View Gene Order

ENSBTAG00000021818

Not yet available

Pathways

NETPATH

REACTOME

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.466039

RefSeq

NM_001025160 NM_001784 NM_078481 XM_005260170 XM_005260171 XM_005260172

HUGO

OMIM

CCDS

CCDS32929 CCDS32930 CCDS32931

HPRD

03130

IMGT

EMBL

GenPept

RNA Seq Atlas