Homo sapiens Gene: CD97
Summary
InnateDB Gene IDBG-33120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD97
Gene Name CD97 molecule
Synonyms TM7LN1;
Species Homo sapiens
Ensembl Gene ENSG00000123146
Encoded Proteins
CD97 molecule
CD97 molecule
CD97 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
Entrez Gene
Summary This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14380501-14408725
Strand Forward strand
Band p13.12
Transcripts
ENST00000242786 ENSP00000242786
ENST00000357355 ENSP00000349918
ENST00000358600 ENSP00000351413
ENST00000586517 ENSP00000467351
ENST00000586849
ENST00000587728
ENST00000590567
ENST00000592341
ENST00000587535
ENST00000593028
ENST00000591080 ENSP00000466040
ENST00000592261 ENSP00000467478
ENST00000587606 ENSP00000465800
ENST00000591737
ENST00000591565
ENST00000587319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466039
RefSeq NM_001025160 NM_001784 NM_078481 XM_005260170 XM_005260171 XM_005260172
HUGO
OMIM
CCDS CCDS32929 CCDS32930 CCDS32931
HPRD 03130
IMGT
EMBL
GenPept
RNA Seq Atlas