|Homo sapiens Gene: CD97|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD97 molecule|
|Useful resources||Stemformatics EHFPI ImmGen|
CD97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
|InnateDB Annotation from Orthologs|
[Mus musculus] Cd97 plays an important role in recruiting granulocytes and possibly macrophages to the sites of infection.
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
|Genomic Location||Chromosome 19:14380501-14408725|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Signaling by GPCR pathway
Signal Transduction pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
|UniProt Splice Variant|
|RefSeq||NM_001025160 NM_001784 NM_078481 XM_005260170 XM_005260171 XM_005260172|
|CCDS||CCDS32929 CCDS32930 CCDS32931|
|RNA Seq Atlas|