InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CX3CL1

Summary

InnateDB Gene

IDBG-33205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CL1

Gene Name

chemokine (C-X3-C motif) ligand 1

Synonyms

ABCD-3; C3Xkine; CXC3; CXC3C; fractalkine; neurotactin; NTN; NTT; SCYD1

Species

Homo sapiens

Ensembl Gene

ENSG00000006210

Encoded Proteins

IDBP-33207

chemokine (C-X3-C motif) ligand 1

IDBP-745844

IDBP-749299

IDBP-750758

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:57372458-57385048

Strand

Forward strand

Band

q21

Transcripts

ENST00000006053	ENSP00000006053
ENST00000564948	ENSP00000457996
ENST00000563383	ENSP00000456830
ENST00000565912	ENSP00000464114

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0019221	cytokine-mediated signaling pathway
GO:0030593	neutrophil chemotaxis
GO:0030595	leukocyte chemotaxis
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0042060	wound healing
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050729	positive regulation of inflammatory response
GO:0050902	leukocyte adhesive activation
GO:0051041	positive regulation of calcium-independent cell-cell adhesion
GO:0060055	angiogenesis involved in wound healing
GO:0060326	cell chemotaxis
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031778

View Gene Order

ENSBTAG00000024869

Not yet available

Pathways

NETPATH

REACTOME

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

P78423

TrEMBL

A0N0N7 H3BSR6 H3BV86 J3QRA1

UniProt Splice Variant

Entrez Gene

6376

UniGene

Hs.531668

RefSeq

NM_002996

HUGO

HGNC:10647

OMIM

601880

CCDS

CCDS10779

HPRD

IMGT

EMBL

AC004382 AC009052 AK313806 BC001163 BC016164 CH471092 EF064745 U84487 U91835

GenPept

AAB49679 AAB50014 AAC24307 AAH01163 AAH16164 ABK41928 BAG36542 EAW82919

RNA Seq Atlas

6376