Homo sapiens Gene: GIPC1
Summary
InnateDB Gene IDBG-33390.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIPC1
Gene Name GIPC PDZ domain containing family, member 1
Synonyms C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP-1; NIP; RGS19IP1; SEMCAP; SYNECTIIN; SYNECTIN; TIP-2;
Species Homo sapiens
Ensembl Gene ENSG00000123159
Encoded Proteins
GIPC PDZ domain containing family, member 1
GIPC PDZ domain containing family, member 1
GIPC PDZ domain containing family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14477760-14496149
Strand Reverse strand
Band p13.12
Transcripts
ENST00000345425 ENSP00000340698
ENST00000393033 ENSP00000376753
ENST00000393028 ENSP00000376748
ENST00000587969 ENSP00000464879
ENST00000591349 ENSP00000467077
ENST00000587934 ENSP00000466624
ENST00000591245 ENSP00000466105
ENST00000589631 ENSP00000466312
ENST00000589497 ENSP00000465003
ENST00000587210 ENSP00000468787
ENST00000585606
ENST00000587811
ENST00000586027 ENSP00000466747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0030165 PDZ domain binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006605 protein targeting
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0014047 glutamate secretion
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031647 regulation of protein stability
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032467 positive regulation of cytokinesis
GO:0043542 endothelial cell migration
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005903 brush border
GO:0005938 cell cortex
GO:0008021 synaptic vesicle
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030139 endocytic vesicle
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655012
RefSeq NM_005716 NM_202468 NM_202469 NM_202470 NM_202494
HUGO
OMIM
CCDS CCDS12310 CCDS12311
HPRD 05462
IMGT
EMBL
GenPept
RNA Seq Atlas