Version 5.4
Homo sapiens Gene: TP53I3
Summary
InnateDB Gene IDBG-33430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP53I3
Gene Name tumor protein p53 inducible protein 3
Synonyms PIG3
Species Homo sapiens
Ensembl Gene ENSG00000115129
Encoded Proteins
IDBP-33432
tumor protein p53 inducible protein 3
IDBP-33436
tumor protein p53 inducible protein 3
IDBP-294910
tumor protein p53 inducible protein 3
IDBP-365968
tumor protein p53 inducible protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24077433-24085861
Strand Reverse strand
Band p23.3
Transcripts
ENST00000335934 ENSP00000337834
ENST00000238721 ENSP00000238721
ENST00000407482 ENSP00000384414
ENST00000417886
ENST00000413037 ENSP00000389620
ENST00000470636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 10 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003960 NADPH:quinone reductase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
GO:0048038 quinone binding
GO:0070402 NADPH binding
Biological Process
GO:0006739 NADP metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50649
RefSeq NM_001206802 NM_004881 NM_147184 XM_006712150
HUGO
OMIM
CCDS CCDS1708 CCDS56112
HPRD 05527
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca