InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53I3

Summary

InnateDB Protein

IDBP-294910.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53I3

Protein Name

tumor protein p53 inducible protein 3

Synonyms

PIG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000384414

InnateDB Gene

IDBG-33430 (TP53I3)

Protein Structure

UniProt Annotation

Function

May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). {ECO:0000269PubMed:19349281}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	10 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003960	NADPH:quinone reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803	protein homodimerization activity
GO:0048038	quinone binding
GO:0070402	NADPH binding

Biological Process

GO:0006739	NADP metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q53FA7