Version 5.4
Homo sapiens Gene: LRWD1
Summary
InnateDB Gene IDBG-33609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRWD1
Gene Name leucine-rich repeats and WD repeat domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161036
Encoded Proteins
IDBP-33611
leucine-rich repeats and WD repeat domain containing 1
IDBP-475022
leucine-rich repeats and WD repeat domain containing 1
IDBP-480274
leucine-rich repeats and WD repeat domain containing 1
IDBP-484789
leucine-rich repeats and WD repeat domain containing 1
IDBP-484231
leucine-rich repeats and WD repeat domain containing 1
IDBP-485204
leucine-rich repeats and WD repeat domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:102464929-102473168
Strand Forward strand
Band q22.1
Transcripts
ENST00000292616 ENSP00000292616
ENST00000463739 ENSP00000420650
ENST00000464107 ENSP00000418204
ENST00000473880
ENST00000476270 ENSP00000417913
ENST00000485808 ENSP00000420729
ENST00000485417
ENST00000468175 ENSP00000420373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding
GO:0035064 methylated histone binding
Biological Process
GO:0006270 DNA replication initiation
GO:0006325 chromatin organization
GO:0016568 chromatin modification
GO:0071169 establishment of protein localization to chromatin
Cellular Component
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
GO:0005721 centromeric heterochromatin
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0031933 telomeric heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029703
View Gene Order
ENSBTAG00000014742
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 222229
UniGene Hs.274135
RefSeq NM_152892 XM_005250204
HUGO HGNC:21769
OMIM 615167
CCDS CCDS34715
HPRD 10904
IMGT
EMBL
GenPept
RNA Seq Atlas 100616367 222229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca