InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRWD1

Summary

InnateDB Protein

IDBP-33611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRWD1

Protein Name

leucine-rich repeats and WD repeat domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292616

InnateDB Gene

IDBG-33609 (LRWD1)

Protein Structure

UniProt Annotation

Function

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269PubMed:20850016, ECO:0000269PubMed:20932478, ECO:0000269PubMed:21029866, ECO:0000269PubMed:22427655, ECO:0000269PubMed:22645314}.

Subcellular Localization

Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.

Disease Associations

Tissue Specificity

Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO:0000269PubMed:17074343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0035064	methylated histone binding

Biological Process

GO:0006270	DNA replication initiation
GO:0006325	chromatin organization
GO:0016568	chromatin modification
GO:0071169	establishment of protein localization to chromatin

Cellular Component

GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005721	centromeric heterochromatin
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0031933	telomeric heterochromatin