Homo sapiens Gene: POLR2J
Summary
InnateDB Gene IDBG-33638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2J
Gene Name polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Synonyms hRPB14; POLR2J1; RPB11; RPB11A; RPB11m;
Species Homo sapiens
Ensembl Gene ENSG00000005075
Encoded Proteins
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:102473118-102478907
Strand Reverse strand
Band q22.1
Transcripts
ENST00000292614 ENSP00000292614
ENST00000393794 ENSP00000377383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0030275 LRR domain binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Formation of the Early Elongation Complex pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
MicroRNA (miRNA) biogenesis pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
mRNA Splicing - Minor Pathway pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Influenza Viral RNA Transcription and Replication pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
Tat-mediated HIV elongation arrest and recovery pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
Dual incision reaction in TC-NER pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase II Pre-transcription Events pathway
mRNA Capping pathway
Transcription of the HIV genome pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
Influenza Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
mRNA Splicing pathway
HIV Transcription Initiation pathway
Formation of the HIV-1 Early Elongation Complex pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
DNA Repair pathway
mRNA Splicing - Major Pathway pathway
Regulatory RNA pathways pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006234 XM_005250452
HUGO
OMIM
CCDS CCDS5724
HPRD 16038
IMGT
EMBL
GenPept
RNA Seq Atlas