InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2J

Summary

InnateDB Protein

IDBP-33642.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2J

Protein Name

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

Synonyms

hRPB14; POLR2J1; RPB11; RPB11A; RPB11m;

Species

Homo sapiens

Ensembl Protein

ENSP00000292614

InnateDB Gene

IDBG-33638 (POLR2J)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9852112}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. High expression was found in heart and skeletal muscle. {ECO:0000269PubMed:11747469}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001055	RNA polymerase II activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0030275	LRR domain binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription