Version 5.4
Homo sapiens Gene: EMR2
Summary
InnateDB Gene IDBG-33739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EMR2
Gene Name egf-like module containing, mucin-like, hormone receptor-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127507
Encoded Proteins
IDBP-33741
egf-like module containing, mucin-like, hormone receptor-like 2
IDBP-244552
egf-like module containing, mucin-like, hormone receptor-like 2
IDBP-244556
egf-like module containing, mucin-like, hormone receptor-like 2
IDBP-764109
IDBP-764876
IDBP-765263
IDBP-764245
IDBP-763562
IDBP-761255
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14732393-14778541
Strand Reverse strand
Band p13.12
Transcripts
ENST00000315576 ENSP00000319883
ENST00000360222
ENST00000392965 ENSP00000376692
ENST00000392962 ENSP00000376689
ENST00000601345 ENSP00000471297
ENST00000594076 ENSP00000472735
ENST00000595839 ENSP00000469277
ENST00000601619
ENST00000595208 ENSP00000469605
ENST00000598500
ENST00000599423
ENST00000594294 ENSP00000470725
ENST00000596991 ENSP00000472280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0035374 chondroitin sulfate binding
Biological Process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0016477 cell migration
GO:0071621 granulocyte chemotaxis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.609531
RefSeq NM_001271052 NM_013447 XM_005259884
HUGO
OMIM
CCDS CCDS32935 CCDS59361
HPRD 07308
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca