Homo sapiens Gene: KRT81
Summary
InnateDB Gene IDBG-34254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT81
Gene Name keratin 81
Synonyms ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137;
Species Homo sapiens
Ensembl Gene ENSG00000205426
Encoded Proteins
keratin 81
keratin 81
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52285913-52291534
Strand Reverse strand
Band q13.13
Transcripts
ENST00000327741 ENSP00000369349
ENST00000615839 ENSP00000483796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005882 intermediate filament
GO:0045095 keratin filament
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.658118 Hs.683440
RefSeq NM_002281
HUGO
OMIM
CCDS CCDS31805
HPRD 03691
IMGT
EMBL
GenPept
RNA Seq Atlas