Homo sapiens Gene: MYOD1
InnateDB Gene IDBG-34281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOD1
Gene Name myogenic differentiation 1
Synonyms bHLHc1; MYF3; MYOD; PUM;
Species Homo sapiens
Ensembl Gene ENSG00000129152
Encoded Proteins
myogenic differentiation 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:17719568-17722131
Strand Forward strand
Band p15.1
ENST00000250003 ENSP00000250003
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 107 [view]
Protein-Protein 102 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0035257 nuclear hormone receptor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007517 muscle organ development
GO:0007518 myoblast cell fate determination
GO:0007519 skeletal muscle tissue development
GO:0009267 cellular response to starvation
GO:0014904 myotube cell development
GO:0014908 myotube differentiation involved in skeletal muscle regeneration
GO:0042692 muscle cell differentiation
GO:0042693 muscle cell fate commitment
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043484 regulation of RNA splicing
GO:0043503 skeletal muscle fiber adaptation
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045445 myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048741 skeletal muscle fiber development
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071453 cellular response to oxygen levels
GO:1901741 positive regulation of myoblast fusion
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0030016 myofibril
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
ID pathway
Developmental Biology pathway
CDO in myogenesis pathway
Myogenesis pathway
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Signal dependent regulation of myogenesis by corepressor mitr [Biocarta view]
Regulation of retinoblastoma protein
Notch-mediated HES/HEY network
C-MYB transcription factor network
Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class III
SwissProt P15172
UniProt Splice Variant
Entrez Gene 4654
UniGene Hs.181768
RefSeq NM_002478
OMIM 159970
EMBL AF027148 BC064493 BT007157 CH471064 X17650 X56677
GenPept AAC29001 AAH64493 AAP35821 CAA35640 CAA40000 EAW68427
RNA Seq Atlas 4654