InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYOD1

Summary

InnateDB Protein

IDBP-34283.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYOD1

Protein Name

myogenic differentiation 1

Synonyms

bHLHc1; MYF3; MYOD; PUM;

Species

Homo sapiens

Ensembl Protein

ENSP00000250003

InnateDB Gene

IDBG-34281 (MYOD1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	107 [view]
Protein-Protein	102 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0035257	nuclear hormone receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007517	muscle organ development
GO:0007518	myoblast cell fate determination
GO:0007519	skeletal muscle tissue development
GO:0009267	cellular response to starvation
GO:0014904	myotube cell development
GO:0014908	myotube differentiation involved in skeletal muscle regeneration
GO:0042692	muscle cell differentiation
GO:0042693	muscle cell fate commitment
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0043484	regulation of RNA splicing
GO:0043503	skeletal muscle fiber adaptation
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045445	myoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048741	skeletal muscle fiber development
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0071453	cellular response to oxygen levels
GO:1901741	positive regulation of myoblast fusion