Version 5.4
Homo sapiens Gene: ZNRF3
Summary
InnateDB Gene IDBG-3438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNRF3
Gene Name zinc and ring finger 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183579
Encoded Proteins
IDBP-294771
zinc and ring finger 3
IDBP-294767
zinc and ring finger 3
IDBP-599452
zinc and ring finger 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 22:28883592-29057487
Strand Forward strand
Band q12.1
Transcripts
ENST00000402174 ENSP00000384456
ENST00000406323 ENSP00000384553
ENST00000544604 ENSP00000443824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0038018 Wnt receptor catabolic process
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0072089 stem cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041961
View Gene Order
ENSBTAG00000022036
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604200 Hs.655242 Hs.732114
RefSeq NM_001206998 NM_032173 XM_005261773 XM_005261774 XM_006724333
HUGO
OMIM
CCDS CCDS42999 CCDS56225
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca