InnateDB Gene
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IDBG-34557.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KRT6B
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Gene Name
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keratin 6B
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Synonyms
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CK-6B; CK6B; K6B; KRTL1; PC2; PC4
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000185479
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 12:52446651-52452126
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Strand
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Reverse strand
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Band
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q13.13
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
|
Protein-Protein |
24
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005198
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structural molecule activity
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GO:0005200
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structural constituent of cytoskeleton
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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P04259
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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3854
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UniGene
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Hs.708950
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RefSeq
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NM_005555
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HUGO
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HGNC:6444
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OMIM
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148042
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CCDS
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CCDS8828
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HPRD |
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IMGT
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EMBL
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AC055736
BC034535
L00198
L00199
L00200
L00201
L00202
L00203
L00204
L00205
L42584
L42585
L42586
L42587
L42588
L42589
L42590
L42592
L42612
M11229
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GenPept
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AAA59466
AAC41768
AAC41771
AAH34535
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RNA Seq Atlas
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3854
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