Version 5.4
Homo sapiens Protein: KRT6B
Summary
InnateDB Protein IDBP-34559.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT6B
Protein Name keratin 6B
Synonyms CK-6B; CK6B; K6B; KRTL1; PC2; PC4;
Species Homo sapiens
Ensembl Protein ENSP00000252252
InnateDB Gene IDBG-34557 (KRT6B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. {ECO:0000269PubMed:9618173}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
Biological Process
GO:0007398 ectoderm development
Cellular Component
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04259
PhosphoSite PhosphoSite-P04259
TrEMBL
UniProt Splice Variant
Entrez Gene 3854
UniGene Hs.708950
RefSeq NP_005546
HUGO HGNC:6444
OMIM 148042
CCDS CCDS8828
HPRD 01012
IMGT
EMBL AC055736 BC034535 L00198 L00199 L00200 L00201 L00202 L00203 L00204 L00205 L42584 L42585 L42586 L42587 L42588 L42589 L42590 L42592 L42612 M11229
GenPept AAA59466 AAC41768 AAC41771 AAH34535

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca