Homo sapiens Gene: INTS6
Summary
InnateDB Gene IDBG-34603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS6
Gene Name integrator complex subunit 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102786
Encoded Proteins
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
integrator complex subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51354077-51454264
Strand Reverse strand
Band q14.3
Transcripts
ENST00000311234 ENSP00000310260
ENST00000398119 ENSP00000381187
ENST00000442263 ENSP00000411245
ENST00000476666
ENST00000469430 ENSP00000417442
ENST00000497989 ENSP00000419871
ENST00000483441
ENST00000490542 ENSP00000419984
ENST00000493153
ENST00000483746 ENSP00000418026
ENST00000460868
ENST00000486195
ENST00000491189 ENSP00000419287
ENST00000466784
ENST00000491723
ENST00000461515
ENST00000491997
ENST00000488009 ENSP00000419144
ENST00000485178 ENSP00000419569
ENST00000483288 ENSP00000417707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.439440 Hs.733376 Hs.734821
RefSeq NM_001039937 NM_001039938 NM_012141
HUGO
OMIM
CCDS CCDS41890 CCDS45048 CCDS9428
HPRD 05063
IMGT
EMBL
GenPept
RNA Seq Atlas