Version 5.4
Homo sapiens Gene: INTS6
Summary
InnateDB Gene IDBG-34603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS6
Gene Name integrator complex subunit 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102786
Encoded Proteins
IDBP-34605
integrator complex subunit 6
IDBP-233790
integrator complex subunit 6
IDBP-368797
integrator complex subunit 6
IDBP-485441
integrator complex subunit 6
IDBP-474861
integrator complex subunit 6
IDBP-479361
integrator complex subunit 6
IDBP-476229
integrator complex subunit 6
IDBP-478573
integrator complex subunit 6
IDBP-474130
integrator complex subunit 6
IDBP-476025
integrator complex subunit 6
IDBP-478996
integrator complex subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51354077-51454264
Strand Reverse strand
Band q14.3
Transcripts
ENST00000311234 ENSP00000310260
ENST00000398119 ENSP00000381187
ENST00000442263 ENSP00000411245
ENST00000476666
ENST00000469430 ENSP00000417442
ENST00000497989 ENSP00000419871
ENST00000483441
ENST00000490542 ENSP00000419984
ENST00000493153
ENST00000483746 ENSP00000418026
ENST00000460868
ENST00000486195
ENST00000491189 ENSP00000419287
ENST00000466784
ENST00000491723
ENST00000461515
ENST00000491997
ENST00000488009 ENSP00000419144
ENST00000485178 ENSP00000419569
ENST00000483288 ENSP00000417707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035161
View Gene Order
ENSBTAG00000002970
Not yet available
Cross-References
SwissProt
TrEMBL C9JAV7
UniProt Splice Variant
Entrez Gene 26512
UniGene Hs.439440 Hs.733376 Hs.734821
RefSeq NM_001039937 NM_001039938 NM_012141
HUGO HGNC:14879
OMIM 604331
CCDS CCDS41890 CCDS45048 CCDS9428
HPRD 05063
IMGT
EMBL AL137780 AL354820
GenPept
RNA Seq Atlas 26512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca