Version 5.4
Homo sapiens Protein: INTS6
Summary
InnateDB Protein IDBP-368797.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS6
Protein Name integrator complex subunit 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000411245
InnateDB Gene IDBG-34603 (INTS6)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. {ECO:0000269PubMed:15254679, ECO:0000269PubMed:16239144}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11939413}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10467397}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
PFAM PF00092
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UL03
PhosphoSite PhosphoSite-Q9UL03
TrEMBL
UniProt Splice Variant
Entrez Gene 26512
UniGene Hs.734821
RefSeq NP_001035027
HUGO HGNC:14879
OMIM 604331
CCDS CCDS45048
HPRD 05063
IMGT
EMBL AF097645 AF141326 AL117626 AL137780 AL354820 AL833524 BC013358 BC018725 BC032386 BC039829 BK005730
GenPept AAD39481 AAF03046 AAH13358 AAH18725 AAH32386 AAH39829 CAB56020 CAI12905 CAI15586 DAA05730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca