InnateDB Protein
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IDBP-368797.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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INTS6
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Protein Name
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integrator complex subunit 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000411245
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InnateDB Gene
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IDBG-34603 (INTS6)
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Protein Structure
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Function |
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. {ECO:0000269PubMed:15254679, ECO:0000269PubMed:16239144}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11939413}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10467397}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002035
von Willebrand factor, type A
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PFAM |
PF00092
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PRINTS |
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PIRSF |
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SMART |
SM00327
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UL03
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PhosphoSite |
PhosphoSite-Q9UL03
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26512
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UniGene |
Hs.734821
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RefSeq |
NP_001035027
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HUGO |
HGNC:14879
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OMIM |
604331
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CCDS |
CCDS45048
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HPRD |
05063
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IMGT |
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EMBL |
AF097645
AF141326
AL117626
AL137780
AL354820
AL833524
BC013358
BC018725
BC032386
BC039829
BK005730
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GenPept |
AAD39481
AAF03046
AAH13358
AAH18725
AAH32386
AAH39829
CAB56020
CAI12905
CAI15586
DAA05730
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