Homo sapiens Gene: ME2
Summary
InnateDB Gene IDBG-3465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ME2
Gene Name malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms ODS1;
Species Homo sapiens
Ensembl Gene ENSG00000082212
Encoded Proteins
malic enzyme 2, NAD(+)-dependent, mitochondrial
malic enzyme 2, NAD(+)-dependent, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:50879049-50954257
Strand Forward strand
Band q21.2
Transcripts
ENST00000321341 ENSP00000321070
ENST00000382927 ENSP00000372384
ENST00000591925
ENST00000585680
ENST00000589330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Pyruvate metabolism pathway
INOH
Glycolysis Gluconeogenesis pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.233119 Hs.603292 Hs.715077
RefSeq NM_001168335 NM_002396
HUGO
OMIM
CCDS CCDS11948 CCDS54187
HPRD 01103
IMGT
EMBL
GenPept
RNA Seq Atlas