InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ME2

Summary

InnateDB Protein

IDBP-3467.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ME2

Protein Name

malic enzyme 2, NAD(+)-dependent, mitochondrial

Synonyms

ODS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000321070

InnateDB Gene

IDBG-3465 (ME2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0008948	oxaloacetate decarboxylase activity
GO:0009055	electron carrier activity
GO:0046872	metal ion binding
GO:0051287	NAD binding

Biological Process

GO:0006108	malate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001891 Malic oxidoreductase
IPR012301 Malic enzyme, N-terminal domain
IPR012302 Malic enzyme, NAD-binding

PFAM

PF00390
PF03949

PRINTS

PR00072

PIRSF

PIRSF000106

SMART

SM00919

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23368

PhosphoSite

PhosphoSite-P23368

TrEMBL

UniProt Splice Variant

Entrez Gene

4200

UniGene

Hs.715077

RefSeq

NP_002387

HUGO

HGNC:6984

OMIM

154270

CCDS

CCDS11948

HPRD

01103

IMGT

EMBL

AB045122 AC015864 AC087687 AJ294818 AK313391 BC000147 CH471096 M55905

GenPept

AAA36197 AAH00147 BAB40980 BAG36189 CAC14574 EAW62980