Homo sapiens Gene: ERAP2
Summary
InnateDB Gene IDBG-34812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERAP2
Gene Name endoplasmic reticulum aminopeptidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164308
Encoded Proteins
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
endoplasmic reticulum aminopeptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96875939-96919716
Strand Forward strand
Band q15
Transcripts
ENST00000379904 ENSP00000369235
ENST00000437043 ENSP00000400376
ENST00000510373 ENSP00000421175
ENST00000513084 ENSP00000421849
ENST00000510309 ENSP00000425758
ENST00000507346 ENSP00000426655
ENST00000508077 ENSP00000427573
ENST00000515095
ENST00000515387
ENST00000513368
ENST00000512869 ENSP00000425415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 64167
UniGene Hs.482910 Hs.649723
RefSeq NM_001130140 NM_022350
HUGO HGNC:29499
OMIM 609497
CCDS CCDS4086
HPRD 14306
IMGT
EMBL
GenPept
RNA Seq Atlas 64167