InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERAP2

Summary

InnateDB Protein

IDBP-484460.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERAP2

Protein Name

endoplasmic reticulum aminopeptidase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000421849

InnateDB Gene

IDBG-34812 (ERAP2)

Protein Structure

UniProt Annotation

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269PubMed:12799365, ECO:0000269PubMed:15908954, ECO:0000269PubMed:16286653}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269PubMed:12799365}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269PubMed:12799365}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006508	proteolysis
GO:0008217	regulation of blood pressure
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I