Version 5.4
Homo sapiens Gene: ALDH3A2
Summary
InnateDB Gene IDBG-34849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH3A2
Gene Name aldehyde dehydrogenase 3 family, member A2
Synonyms ALDH10; FALDH; SLS
Species Homo sapiens
Ensembl Gene ENSG00000072210
Encoded Proteins
IDBP-34851
aldehyde dehydrogenase 3 family, member A2
IDBP-34853
aldehyde dehydrogenase 3 family, member A2
IDBP-239275
aldehyde dehydrogenase 3 family, member A2
IDBP-372522
aldehyde dehydrogenase 3 family, member A2
IDBP-763930
IDBP-760798
IDBP-758570
IDBP-762418
IDBP-764865
IDBP-758355
IDBP-763091
IDBP-759079
IDBP-759970
IDBP-764481
IDBP-762195
IDBP-758869
IDBP-763397
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19648136-19677598
Strand Forward strand
Band p11.2
Transcripts
ENST00000176643 ENSP00000176643
ENST00000339618 ENSP00000345774
ENST00000395575 ENSP00000378942
ENST00000446398 ENSP00000395845
ENST00000467473
ENST00000472059 ENSP00000458397
ENST00000476965
ENST00000579403
ENST00000575384 ENSP00000461235
ENST00000579855 ENSP00000463637
ENST00000578614 ENSP00000463128
ENST00000574078
ENST00000578696 ENSP00000464453
ENST00000584332 ENSP00000466814
ENST00000580550 ENSP00000462964
ENST00000582991 ENSP00000464153
ENST00000573505
ENST00000573565 ENSP00000463924
ENST00000573947 ENSP00000462933
ENST00000574597
ENST00000571537 ENSP00000458942
ENST00000571163 ENSP00000459977
ENST00000581518 ENSP00000461916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046577 long-chain-alcohol oxidase activity
GO:0050061 long-chain-aldehyde dehydrogenase activity
GO:0052814 medium-chain-aldehyde dehydrogenase activity
Biological Process
GO:0006081 cellular aldehyde metabolic process
GO:0006714 sesquiterpenoid metabolic process
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0008152 metabolic process
GO:0008218 bioluminescence
GO:0008544 epidermis development
GO:0033306 phytol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010025
View Gene Order
ENSBTAG00000039161
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00340
Histidine metabolism pathway
hsa00620
Pyruvate metabolism pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00330
Arginine and proline metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00071
Fatty acid degradation pathway
hsa00310
Lysine degradation pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00561
Glycerolipid metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Pyruvate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499886 Hs.610237 Hs.610493 Hs.636230 Hs.737600
RefSeq NM_000382 NM_001031806
HUGO
OMIM
CCDS CCDS11210 CCDS32589
HPRD 07188
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca