Homo sapiens Gene: KRT2
Summary
InnateDB Gene IDBG-34857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT2
Gene Name keratin 2
Synonyms CK-2e; K2e; KRT2A; KRT2E; KRTE;
Species Homo sapiens
Ensembl Gene ENSG00000172867
Encoded Proteins
keratin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52644558-52652164
Strand Reverse strand
Band q13.13
Transcripts
ENST00000309680 ENSP00000310861
ENST00000547106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
Biological Process
GO:0008544 epidermis development
GO:0031424 keratinization
GO:0032980 keratinocyte activation
GO:0043616 keratinocyte proliferation
GO:0051546 keratinocyte migration
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.707
RefSeq NM_000423
HUGO
OMIM
CCDS CCDS8835
HPRD 02560
IMGT
EMBL
GenPept
RNA Seq Atlas