Homo sapiens Gene: CYP4F3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-34860.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CYP4F3 | ||||||||||||||||||
Gene Name | cytochrome P450, family 4, subfamily F, polypeptide 3 | ||||||||||||||||||
Synonyms | CPF3; CYP4F; LTB4H | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000186529 | ||||||||||||||||||
Encoded Proteins |
cytochrome P450, family 4, subfamily F, polypeptide 3
cytochrome P450, family 4, subfamily F, polypeptide 3
cytochrome P450, family 4, subfamily F, polypeptide 3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 19:15615617-15662825 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p13.12 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Arachidonic acid metabolism pathway
Fatty acids pathway
Miscellaneous substrates pathway
Eicosanoids pathway
Metabolism of lipids and lipoproteins pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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KEGG |
Arachidonic acid metabolism pathway
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INOH |
Prostaglandin Leukotriene metabolism pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q08477 | ||||||||||||||||||
TrEMBL | A0A024R7I2 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 4051 | ||||||||||||||||||
UniGene | Hs.106242 | ||||||||||||||||||
RefSeq | NM_001199209 NM_000896 NM_001199208 XM_006722751 | ||||||||||||||||||
HUGO | HGNC:2646 | ||||||||||||||||||
OMIM | 601270 | ||||||||||||||||||
CCDS | CCDS59362 CCDS12332 | ||||||||||||||||||
HPRD | 03169 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB002454 AB002461 AD000685 AF054821 AK304200 AK316136 AY792513 BC136299 CH471106 D12620 D12621 | ||||||||||||||||||
GenPept | AAC08589 AAI36300 AAV40834 BAA02144 BAA02145 BAA25990 BAA25991 BAH14129 BAH14507 EAW84489 EAW84491 | ||||||||||||||||||
RNA Seq Atlas | 4051 | ||||||||||||||||||