Version 5.4
Homo sapiens Gene: LDHA
Summary
InnateDB Gene IDBG-34863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDHA
Gene Name lactate dehydrogenase A
Synonyms GSD11; HEL-S-133P; LDH1; LDHM
Species Homo sapiens
Ensembl Gene ENSG00000134333
Encoded Proteins
IDBP-34865
lactate dehydrogenase A
IDBP-34867
lactate dehydrogenase A
IDBP-237909
lactate dehydrogenase A
IDBP-368505
lactate dehydrogenase A
IDBP-368506
lactate dehydrogenase A
IDBP-584576
lactate dehydrogenase A
IDBP-601342
lactate dehydrogenase A
IDBP-585313
lactate dehydrogenase A
IDBP-586019
lactate dehydrogenase A
IDBP-597736
lactate dehydrogenase A
IDBP-589429
lactate dehydrogenase A
IDBP-584965
lactate dehydrogenase A
IDBP-603097
lactate dehydrogenase A
IDBP-592082
lactate dehydrogenase A
IDBP-587790
lactate dehydrogenase A
IDBP-601824
lactate dehydrogenase A
IDBP-587593
lactate dehydrogenase A
IDBP-588186
lactate dehydrogenase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:18394388-18408425
Strand Forward strand
Band p15.1
Transcripts
ENST00000227157 ENSP00000227157
ENST00000379412 ENSP00000368722
ENST00000375710
ENST00000396222 ENSP00000379524
ENST00000422447 ENSP00000395337
ENST00000430553 ENSP00000406172
ENST00000469976
ENST00000494573
ENST00000478970 ENSP00000441241
ENST00000495052 ENSP00000446415
ENST00000486690 ENSP00000441699
ENST00000460405
ENST00000543445 ENSP00000440161
ENST00000545467 ENSP00000443545
ENST00000535451 ENSP00000444292
ENST00000539814 ENSP00000442979
ENST00000543695 ENSP00000440368
ENST00000536528 ENSP00000441058
ENST00000541097 ENSP00000443362
ENST00000545215 ENSP00000442637
ENST00000542179 ENSP00000445331
ENST00000537296
ENST00000538451
ENST00000540430 ENSP00000445175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 73 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0021762 substantia nigra development
GO:0031668 cellular response to extracellular stimulus
GO:0044237 cellular metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0035686 sperm fibrous sheath
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063229
View Gene Order
ENSBTAG00000008683
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_2071
Pyruvate metabolism pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
INOH website
Methionine Cysteine metabolism pathway
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt P00338
TrEMBL F5GXH2 F5GXY2 F5GZQ4 F5H8H6 V9HWB9
UniProt Splice Variant
Entrez Gene 3939
UniGene Hs.2795 Hs.575669
RefSeq NM_001135239 NM_001165414 NM_001165415 NM_001165416 NM_005566
HUGO HGNC:6535
OMIM 150000
CCDS CCDS7839 CCDS44549 CCDS53609 CCDS53610 CCDS53611
HPRD 01025
IMGT
EMBL AC084117 AK130587 AK223078 AK296667 AK298834 AY423727 BC067223 CH471064 CR456775 CR541714 EU794632 S66853 X02152 X03077 X03078 X03079 X03080 X03081 X03082 X03083
GenPept AAB20418 AAH67223 AAS00490 ACJ13686 BAC85389 BAD96798 BAG59264 BAH12879 CAA26088 CAA26879 CAG33056 CAG46515 EAW68395 EAW68396
RNA Seq Atlas 3939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca