InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LDHA

Summary

InnateDB Protein

IDBP-237909.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDHA

Protein Name

lactate dehydrogenase A

Synonyms

GSD11; HEL-S-133P; LDH1; LDHM;

Species

Homo sapiens

Ensembl Protein

ENSP00000379524

InnateDB Gene

IDBG-34863 (LDHA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269PubMed:2334430}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	73 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004459	L-lactate dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006096	glycolytic process
GO:0021762	substantia nigra development
GO:0044237	cellular metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001236 Lactate/malate dehydrogenase, N-terminal
IPR001557 L-lactate/malate dehydrogenase
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383 Lactate/malate dehydrogenase, C-terminal

PFAM

PF00056
PF02866

PRINTS

PR00086

PIRSF

PIRSF000102

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt